Molecular and Functional MRI of the Tumor Microenvironment
نویسندگان
چکیده
منابع مشابه
Molecular and Functional MRI of the Tumor Microenvironment
In malignant tumors, cancer cells are embedded within a complex microenvironment consisting of the extracellular matrix (ECM), blood and lymphatic vessels, infiltrating leukocytes, fibroblasts, and other stromal cells. This microenvironment is characterized by abnormal physiologic conditions such as hypoxia and acidic extracellular pH, generated largely by the chaotic tumor vasculature and lack...
متن کاملMolecular and functional MRI of the tumor microenvironment.
In malignant tumors, cancer cells are embedded within a complex microenvironment consisting of the extracellular matrix (ECM), blood and lymphatic vessels, infiltrating leukocytes, fibroblasts, and other stromal cells. This microenvironment is characterized by abnormal physiologic conditions such as hypoxia and acidic extracellular pH, generated largely by the chaotic tumor vasculature and lack...
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15 صفحه اولMRI of the tumor microenvironment.
The microenvironment within tumors is significantly different from that in normal tissues. A major difference is seen in the chaotic vasculature of tumors, which results in unbalanced blood supply and significant perfusion heterogeneities. As a consequence, many regions within tumors are transiently or chronically hypoxic. This exacerbates tumor cells' natural tendency to overproduce acids, res...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2008
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.107.043349